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Genotypic analysis of Mycobacterium leprae isolates from Japan and other Asian countries reveals a global transmission pattern of leprosy
Authors:Matsuoka Masanori  Roa Rocio Ivette Lopez  Budiawan Teky  Kyaw Kyaw  Chae Gue-Tae
Affiliation:Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan. matsuoka@nih.go.jp
Abstract:The genotype of single-nucleotide polymorphism type 3, CTC, at positions 14676, 164275, and 2935685, along with four copies of 6 bp repeats in the rpoT gene, was predominant for isolates originating in the Japanese mainland. Type 1, CGA, type 2, CTA, and type 3 were detected from Korea, Indonesia, and Myanmar. No isolates with four copies of 6 bp were detected from Myanmar, Okinawa, and Japanese Brazilian patients. Type 4, TTC, with three copies of 6 bp, was detected only from Japanese Brazilians. The results indicate that infection occurred in Brazil and the disease developed later in Japan.
Keywords:leprosy    Mycobacterium leprae    genotyping    SNPs    VNTRs
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