Regulation of nebramycin biosynthesis by inorganic phosphate |
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Authors: | T K Todorov N Mikhailova-Ivanova M Blum Uerová |
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Institution: | (1) Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;(2) Research Institute of Microbial Products, 7200 Razgrad, Bulgaria;(3) Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4, Czechoslovakia |
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Abstract: | The effect of inorganic phosphate on the biosynthesis of nebramycin factors2, 4 and5′ was studied inStreptomyces tenebrarius strain A (forming2, 4 and5′ in natural ratios) and its mutants B (forming predominantly2), C (forming2 as the only major product) and D (forming predominantly5′). In phosphate-supplemented complex media, the production of2 in A, B and C was reduced by 20–70%, while the yields of5′ remained unchanged in A and decreased by 30–60% in B. The production of4 increased by 50–90% in A and was fully suppressed in B. In D the biosynthesis of the three factors was inhibited completely. |
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