New PEG2 type polyethylene glycol derivatives for protein modification |
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| Authors: | Motoo Yamasaki Masami Okabe Toshiyuki Suzawa Yoshiharu Yokoo |
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| Institution: | (1) Tokyo Research Laboratories, Kyowa Hakko Kogyo Co Ltd, 3–6–6 Asahi-machi Machida-shi Tokyo, Japan;(2) Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, Suntou-gun Shizuoka, Japan |
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| Abstract: | Although proteins with 2,4-bis (o-methoxypolyethylene glycol)-6-chloro-s-triazine (PEG2-Cl) as a divalent PEG modification have some advantages compared to proteins with the linear PEG modification, PEG2Cl cannot react with amino groups at neutral pH. Therefore, we have prepared new PEG2 derivatives that have an activated ester as the functional group. We confirmed that these derivatives are useful for the divalent modification of proteins, such as bSOD and rhG-CSF. © Rapid Science Ltd. 1998 |
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| Keywords: | chemical modification granulocyte colony-stimulating factor polyethylene glycol superoxide dismutase |
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