Rat liver lysosome membranes are enriched in alpha-tocopherol. |
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| Authors: | C A Rupar S Albo J D Whitehall |
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| Institution: | Department of Biochemistry, University of Western Ontario, London, Canada. |
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| Abstract: | The subcellular distribution of alpha-tocopherol has been studied in rat liver. Lysosomal membranes were found to be considerably enriched in alpha-tocopherol with 6300 pmol/mg membrane protein, whereas mitochondrial membranes and microsomes contained 530 and 200 pmol/mg membrane protein, respectively. The 37-fold higher specific content of alpha-tocopherol in lysosomal membranes relative to homogenate indicates that lysosomes could be a target of cellular pathology in vitamin E deficiency states. |
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