The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity |
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| Authors: | Chin‐Feng Hsuan Chih‐Kun Huang Jou‐Wei Lin Lung‐Chun Lin Thung‐Lip Lee Chi‐Ming Tai Wei‐Hsian Yin Wei‐Kung Tseng Kwan‐Lih Hsu Chau‐Chung Wu |
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| Institution: | 1. Department of Internal medicine, E‐Da Hospital, Kaohsiung, Taiwan;2. Institute of Biotechnology and Chemical Engineering, I‐Shou University, Kaohsiung, Taiwan;3. Department of Surgery, E‐Da Hospital, Kaohsiung, Taiwan;4. Cardiovascular Center, National Taiwan University Hospital Yun‐Lin Branch, Yun‐Lin, Taiwan;5. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;6. Division of Cardiology, Cheng‐Hsin General Hospital, Taipei, Taiwan;7. Department of Medical Imaging and Radiological Sciences, I‐Shou University, Kaohsiung, Taiwan |
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| Abstract: | The aim of this study was to examine the effect of surgical weight reduction on cardiac structure and function and to seek the determinants of these changes. Sixty‐six severely obese adults (BMI ≥35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months after surgery. At 3 months after surgery, BMI and systolic blood pressure (BP) decreased (43.3 ± 6.3 to 34.1 ± 5.6 kg/m2, P < 0.001, and 146 ± 12 to 130 ± 14 mm Hg, P < 0.001, respectively). In left ventricular (LV) geometry, the relative wall thickness (RWT) and LV mass index decreased significantly (0.43 ± 0.05 to 0.35 ± 0.05, P < 0.001, and 50 ± 11 to 39 ± 11 g/m2.7, P < 0.001, respectively) without changes in chamber size. Multivariate analyses showed change in systolic BP to be an independent predictor for the changes in RWT and LV mass index. In myocardial performance, peak systolic mitral annular velocity and all diastolic indexes showed significant improvements. We concluded that LV hypertrophy and function improved rapidly after bariatric surgery in severely obese adults. BP reduction was the major determinant for the regression of LV hypertrophy in the early stage of surgical weight reduction. |
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