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Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals
Authors:Carole Henry  Nai-Ying Zheng  Min Huang  Alexandra Cabanov  Karla Thatcher Rojas  Kaval Kaur  Sarah F. Andrews  Anna-Karin E. Palm  Yao-Qing Chen  Yang Li  Katerina Hoskova  Henry A. Utset  Marcos C. Vieira  Jens Wrammert  Rafi Ahmed  Jeanne Holden-Wiltse  David J. Topham  John J. Treanor  Patrick C. Wilson
Affiliation:1. Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, USA;2. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA;4. Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30317, USA;5. Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30317, USA;6. Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA;7. Center for Vaccine Biology & Immunology, Department of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA;8. Division of Infectious Disease, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA;9. The Wistar Institute Vaccine and Immunotherapy Center, Philadelphia, PA 19104, USA;10. Division of Geriatrics, Duke University Medical Center and GRECC, Durham VA Medical Center, Durham, NC 27710, USA;11. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;12. Departments of Medicine and Immunology and Microbiology, Stanford University School of Medicine, Stanford, CA 94305, USA;13. VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
Abstract:
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  • Keywords:influenza vaccine  elderly population  immunoglobulin genes  monoclonal antibodies
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