Single‐nucleotide Polymorphism of CD36 Locus and Obesity in European Adolescents |
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| Authors: | Szilvia Bokor Vanessa Legry Aline Meirhaeghe Jonatan R. Ruiz Beatrice Mauro Kurt Widhalm Yannis Manios Philippe Amouyel Luis A. Moreno Dènes Molnàr Jean Dallongeville HELENA Study group |
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| Affiliation: | 1. Department of Epidemiology and Public Health, Institut Pasteur de Lille, INSERM, U744, Université Lille Nord de France, UDSL, Lille, France;2. Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Stockholm, Sweden;3. Department of Physiology, School of Medicine, University of Granada, Granada, Spain;4. Research Department, INRAN, National Research Institute for Food and Nutrition, Rome, Italy;5. Department of Pediatrics, Division of Clinical Nutrition and Prevention, Medical University of Vienna, Vienna, Austria;6. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece;7. GENUD (Growth, Exercise, Nutrition and Development) Research Group, Escuela Universitaria de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Spain;8. Department of Paediatrics, University of Pècs, Pècs, Hungary |
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| Abstract: | CD36 is a membrane receptor with a wide variety of functions, including the regulation of energy metabolism, fat storage, and adipocyte differentiation. To assess the relationship between CD36 gene single‐nucleotide polymorphisms (SNPs) and obesity in adolescents, we evaluated the relationship between CD36 SNPs and the risk of obesity in a case–control study composed of 307 obese (age = 15.0 ± 1.1 years) and 339 normal‐weight adolescents (age = 14.6 ± 1.1 years). To validate the results, we assessed the relation between the same SNPs and percentage of body fat (BF%) and BMI in 1,151 European adolescents (age = 14.8 ± 1.4 years). SNPs with a minor allele frequency >0.10 were selected to tag CD36. Genotyping was performed on an Illumina system. Four SNPs (rs3211867, rs3211883, rs3211908, and rs1527483) were associated with increased risk of obesity in the case–control study (odds ratio (OR) (95% confidence interval)): 1.96 (1.26–3.04], P = 0.003; 1.73 (1.16–2.59), P = 0.007; 2.42 (1.47–4.01), P = 0.0005 and 1.95 (1.25–3.05), P = 0.003, respectively). The same four SNPs were associated with higher BMI (P < 0.05) and BF% (P < 0.04) in the validation study. Further analyses identified a haplotype (frequency: 0.05) carrying the minor allele of these SNPs as being associated with obesity (OR: 2.28; P = 0.0008) in the case–control study and with excess adiposity (i.e., higher BF% (P = 0.03) and BMI (P = 0.04)) in the validation study. Our data suggest that genetic variability at the CD36 gene locus could be associated with body weight variability in European adolescents but these findings require replication. |
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