Genetic polymorphisms of the bovine Fatty acid binding protein 4 gene are significantly associated with marbling and carcass weight in Hanwoo (Korean Cattle) |
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| Authors: | S H Lee J H J Van Der Werf S H Lee E W Park S J Oh J P Gibson J M Thompson |
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| Institution: | 1. Animal Genome & Bioinformatics Division, National Institute of Animal Science, RDA, Suwon 441‐701, Korea;2. The Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, NSW 2351, Australia;3. School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia;4. Queensland Institute of Medical Research, Brisbane, Qld 4029, Australia |
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| Abstract: | The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re‐sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT (P = 0.01) and the g.3631G allele was associated with higher marbling score (P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT (P = 0.02) and marbling score (P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg). |
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| Keywords: | carcass weight Fatty Acid Binding Protein 4 marbling score |
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