Variation in chicken populations may affect the enzymatic activity of lysozyme |
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| Authors: | T. Downing C. O’Farrelly A. K. Bhuiyan P. Silva A. N. Naqvi R. Sanfo R.‐S. Sow B. Podisi O. Hanotte D. G. Bradley |
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| Affiliation: | 1. Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin, Ireland.;2. Present address: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom CB10 1SA;3. School of Biochemistry and Immunology, Trinity College, University of Dublin, Dublin, Ireland.;4. Department of Animal Breeding and Genetics, Bangladesh Agricultural University, Mymensingh, Bangladesh.;5. Department of Animal Science, University of Peradeniya, Peradeniya, Sri Lanka.;6. PARC, Animal Sciences Division, Islamabad, Pakistan.;7. INERA, Agriculture and Environment, Ouagadougou, Burkina Faso.;8. Institut Sénégalais de Recherches Agricoles, Dakar, Senegal.;9. Department of Agricultural Research, CTA, Gaborone, Botswana.;10. School of Biology, University of Nottingham, Nottingham, United Kingdom NG7 2RD and International Livestock Research Institute (ILRI), PO Box 30709, Nairobi 00100, Kenya |
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| Abstract: | The chicken lysozyme gene encodes a hydrolase that has a key role in defence, especially in ovo. This gene was resequenced in global chicken populations [red, grey, Ceylon and green jungle fowl (JF)] and related bird species. Networks, summary statistics and tests of neutrality indicate that although there is extensive variation at the gene, little is present at coding sites, with the exception of one non‐synonymous site. This segregating site and a further fixed non‐synonymous change between red JF and domestic chicken populations are spatially close to the catalytic sites of the enzyme and so might affect its activity. |
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| Keywords: | chicken domestication jungle fowl lysozyme population genetics |
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