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Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations
Authors:Jiwon Lee  Philipp Paparoditis  Andrew P Horton  Alexander Frühwirth  Jonathan R McDaniel  Jiwon Jung  Daniel R Boutz  Dania A Hussein  Yuri Tanno  Leontios Pappas  Gregory C Ippolito  Davide Corti  Antonio Lanzavecchia  George Georgiou
Institution:1. Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA;2. Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona 6500, Switzerland;3. Institute of Microbiology, ETH Zürich, Zürich 8093, Switzerland;4. Center for Systems and Synthetic Biology, The University of Texas at Austin, Austin, TX 78712, USA;5. Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA;6. Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA;7. Humabs BioMed, Bellinzona 6500, Switzerland
Abstract:
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  • Keywords:influenza vaccine response  serum antibody repertoire  immunological imprinting  humoral immunity  anti-hemagglutinin antibodies  persistent antibodies  longitudinal profiling
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