Spatial organization of adhesion: force‐dependent regulation and function in tissue morphogenesis |
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Authors: | Ekaterina Papusheva Carl‐Philipp Heisenberg |
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Affiliation: | Institute of Science and Technology Austria, Klosterneuburg, Austria |
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Abstract: | Integrin‐ and cadherin‐mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force‐mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis. |
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Keywords: | adhesion spatial organization tissue morphogenesis |
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