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Novel mechanism of inhibiting beta-lactamases by sulfonylation using beta-sultams |
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| Authors: | Page Michael I Hinchliffe Paul S Wood J Matthew Harding Lindsay P Laws Andrew P |
| Institution: | Department of Chemical and Biological Sciences, The University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK |
| Abstract: | β-Sultams are the sulfonyl analogues of β-lactams and N-acyl β-sultams are novel inactivators of the class C β-lactamase of Enterobacter cloacae P99. The rates of inactivation show a similar pH-rate dependence as that exhibited by the β-lactam antibiotics and with ESIMS data it is suggested that β-sultams sulfonylate the active site serine residue to form a sulfonate ester. |
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