Effective accumulation of polyion complex micelle to experimental choroidal neovascularization in rats |
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Authors: | Ideta Ryuichi Yanagi Yasuo Tamaki Yasuhiro Tasaka Fumitaka Harada Atsushi Kataoka Kazunori |
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Institution: | Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. |
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Abstract: | Exudative age-related macular degeneration, characterized by choroidal neovascularization (CNV), is a major cause of visual loss. In this study, we examined the distribution of the polyion complex (PIC) micelle encapsulating FITC-P(Lys) in blood and in experimental CNV in rats to investigate whether PIC micelle can be used for treatment of CNV. We demonstrate that PIC micelle has long-circulating characteristics, accumulating to the CNV lesions and is retained in the lesion for as long as 168 h after intravenous administration. These results raise the possibility that PIC micelles can be used for achieving effective drug targeting to CNV. |
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