Differential activation of MAP kinase family members triggered by CD99 engagement |
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Authors: | Hahn M J Yoon S S Sohn H W Song H G Park S H Kim T J |
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Institution: | Department of Microbiology, Sungkyunkwan University School of Medicine, Suwon, South Korea. |
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Abstract: | The molecular basis for the modulatory properties of CD99 is not well understood. Treatment of human Jurkat T lymphocytes with anti-CD99 antibody led to activation of three mitogen-activated protein kinase (MAPK) members, ERK, JNK, and p38 MAPK, along with homotypic aggregation. While phosphorylation of ERK and JNK was inhibited by the pretreatment of a PKC inhibitor, bisindolylmaleimide I, activation of p38 MAPK was upregulated by the same pretreatment. The signaling pathways to MAPKs by CD99 engagement were independent of PI-3 kinase, distinguishing from those by CD3 engagement. Among MAPKs, ERK pathway was essential for homotypic aggregation together with intracytoplasmic Ca(2+). |
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Keywords: | T lymphocyte Cellular activation Signal transduction Cell surface molecule Protein kinase/phosphatase |
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