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Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium |
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| Authors: | Wang Denong Carroll Gregory T Turro Nicholas J Koberstein Jeffrey T Kovác Pavol Saksena Rina Adamo Roberto Herzenberg Leonore A Herzenberg Leonard A Steinman Lawrence |
| Institution: | Carbohydrate Microarray Laboratory, Stanford University School of Medicine, Stanford, CA, USA. dwang1@stanford.edu |
| Abstract: | Using photogenerated glycan arrays, we characterized a large panel of synthetic carbohydrates for their antigenic reactivities with pathogen-specific antibodies. We discovered that rabbit IgG antibodies elicited by Bacillus anthracis spores specifically recognize a tetrasaccharide chain that decorates the outermost surfaces of the B. anthracis exosporium. Since this sugar moiety is highly specific for the spores of B. anthracis, it appears to be a key biomarker for detection of B. anthracis spores and development of novel vaccines that target anthrax spores. |
| Keywords: | Antibody Bacteria Biomarker Carbohydrates Sugar chips |
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