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Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides |
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| Authors: | Cumming John G Cooper Anne E Grime Ken Logan Chris J McLaughlin Sharon Oldfield John Shaw John S Tucker Howard Winter Jon Whittaker David |
| Institution: | Respiratory & Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. john.cumming@astrazeneca.com |
| Abstract: | SAR and DMPK studies led to the identification of substituted N-alkyl-N-1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5 chemokine receptor. |
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| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |