Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers |
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| Authors: | Slifka M K Whitton J L |
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| Affiliation: | Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA. mslifka@scripps.edu |
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| Abstract: | Dissecting the mechanisms of T cell-mediated immunity requires the identification of functional characteristics and surface markers that distinguish between activated and memory T lymphocytes. In this study, we compared the rates of cytokine production by virus-specific primary and memory CD8+ T cells directly ex vivo. Ag-specific IFN-gamma and TNF-alpha production by both primary and long-term memory T cells was observed in
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