Objective comparison of exon and intron sequences by means of 2-dimensional data analysis methods |
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Authors: | L Bougueleret F Tekaia I Sauvaget J M Claverie |
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Institution: | Computer Science Unit, Institut Pasteur, Paris, France. |
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Abstract: | Here we advocate the use of 2-dimensional data representation in the context of the informational approach of sequence analysis (Claverie & Bougueleret (1986) Nucleic Acids Research 14, 179-196) by applying these methods to the problem of intron/exon discrimination. Two main findings are reported: i) oligonucleotide patterns complementary to the Ul small nuclear RNA are specifically avoided in exon sequences, ii) vertebrate intron sequences, to the exclusion of other eukaryotic phyla, are characterized by a peculiar distribution of CpG containing patterns. |
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