The regulation of mitochondrial physiology by organelle-associated GTP-binding proteins |
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Authors: | Thomson Murray |
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Institution: | School of Biological Sciences, University of Sydney, Camperdown NSW 2006, Australia. mthomson@bio.usyd.edu.au |
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Abstract: | Recent studies have shown that GTP-binding proteins can modulate mitochondrial membrane fusion and fission. Furthermore, GTP-binding proteins can regulate the binding of ribosomes to the mitochondrial membrane and may facilitate the import of proteins through contact points between inner and outer mitochondrial membranes. Mitochondrial GTP-binding proteins therefore appear to have the potential to modulate physiological function of the organelle and may also be involved in cellular processes such as cellular transformation. A beginning has been made on the characterization of mitochondrial GTP-binding proteins and the DNA sequence of one protein has become newly available. Future studies are needed to determine whether GTP-binding proteins are interacting with cell signalling molecules such as protein kinases in the mitochondria. |
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Keywords: | GTP‐binding proteins mitochondria membrane fusion protein import |
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