Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells |
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| Authors: | Lee Jeeyun Im Young-Hyuck Jung Hae Hyun Kim Joo Hyun Park Joon Oh Kim Kihyun Kim Won Seog Ahn Jin Seok Jung Chul Won Park Young Suk Kang Won Ki Park Keunchil |
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| Affiliation: | Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. |
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| Abstract: | The A549 cells, non-small cell lung cancer cell line from human, were resistant to interferon (IFN)-alpha treatment. The IFN-alpha-treated A549 cells showed increase in protein expression levels of NF-kappaB and COX-2. IFN-alpha induced NF-kappaB binding activity within 30 min and this increased binding activity was markedly suppressed with inclusion of curcumin. Curcumin also inhibited IFN-alpha-induced COX-2 expression in A549 cells. Within 10 min, IFN-alpha rapidly induced the binding activity of a gamma-(32)P-labeled consensus GAS oligonucleotide probe, which was profoundly reversed by curcumin. Taken together, IFN-alpha-induced activations of NF-kappaB and COX-2 were inhibited by the addition of curcumin in A549 cells. |
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| Keywords: | Curcumin Cyclooxygenase-2 Interferon-α NF-κB Non-small cell lung cancer |
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