Effects of reciprocal interactions between various dietary fats and circadian phases on postprandial hyperlipidemia in rats |
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| Authors: | Basri Satılmış Başak Kayhan Tayfun Güldür |
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| Affiliation: | 1. Hepatology Research Laboratory, Liver Transplantation Institute, ?n?nü University, Malatya, Turkeybasri.satilmis@inonu.edu.tr;3. Faculty of Medicine, Department of Medical Biology and Genetics, ?n?nü University, Malatya, Turkey;4. Faculty of Medicine, Department of Medical Biochemistry, ?n?nü University, Malatya, Turkey |
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| Abstract: | Expression levels of various intestinal proteins involved in postprandial lipoprotein assembly as well as plasma triglyceride concentration exhibit daily oscillations indicating circadian control. The length of the carbon chain and degree and position of unsaturation of fatty acids influence triglyceride secretion by the enterocytes. To this end, effects of reciprocal interactions of various single fats/oil (olive oil, fish oil or butter) gavaging either in active or passive phase were investigated in rats. Fat/oil gavaged in the active phase of circadian rhythm resulted in higher postprandial serum triglyceride levels compared to that in the passive phase. Moreover, olive oil led to higher MTP activity and apo B-48 gene expression, while fish oil gavaging caused more prominent apo B-48 and MTP gene expression when they were given in the passive phase. The present results indicate that circadian time at which fat or oil gavaged once might exert influence on postprandial lipoprotein synthesis/assembly. |
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| Keywords: | Circadian rhythms dietary fats chylomicron hyperlipidemia microsomal triglyceride transfer protein |
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