Green tea extracts reduce leukocyte cell–Derived chemotaxin 2 and selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat diet |
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| Authors: | Shintaro Onishi Hidefumi Kitazawa Ichiro Tokimitsu |
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| Institution: | 1. Biological Science Research, Kao Corporation, Tochigi, Japan;2. Industry–Academia Collaboration Research Laboratory of the University of Shizuoka and Kao Corporation, University of Shizuoka, Shizuoka, Japan;3. Industry–Academia Collaboration Research Laboratory of the University of Shizuoka and Kao Corporation, University of Shizuoka, Shizuoka, Japan;4. Department of Health and Food Science, University of Human Arts and Science, Magome, Iwatsuki-ku, Saitama-shi, Saitama, Japan |
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| Abstract: | Epidemiological studies suggest that green tea extracts (GTEs), including catechins such as epigallocatechin gallate and epicatechin gallate, have a beneficial effect on obesity, hyperglycemia, insulin resistance, endothelial dysfunction, and inflammation. Although several studies have shown that catechins directly modulate the cellular and molecular alterations in the liver tissue, the contributions of indirect mechanisms underlying these systemic effects of catechins remain unclear. In this study, we report that, in the C57BL/6J mouse liver, GTEs reduce high-fat diet-induced increases in the levels of hepatokines, liver-derived secretary proteins such as leukocyte cell-derived chemotaxin 2 and selenoprotein P production, which have been shown to induce systemic adverse effects, including several metabolic diseases. These findings suggest that the systemic effects of GTEs involve the regulation of hepatokine production as an indirect mechanism. |
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| Keywords: | Green tea extract high-fat leukocyte cell-derived chemotaxin 2 selenoprotein P |
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