Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence |
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| Authors: | Hirofumi Inoue Nobuaki Hanawa Rie Katsumata-Tsuboi Shi-Ichi Katsumata Nobuyuki Takahashi |
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| Institution: | 1. Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety, Tokyo University of Agriculture, Tokyo, Japan;2. Faculty of Applied Bioscience, Department of Food and Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan |
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| Abstract: | To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray. Furthermore, DFO treatment increased senescence marker β-galactosidase activity, whereas this activity was attenuated by overexpression of SMP30. Our data suggested that down-regulation of SMP30 drives cell senescence in iron-chelated condition. |
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| Keywords: | Senescence marker protein 30 deferoxamine cell senescence β-galactosidase activity |
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