Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor,BRD4-P-TEFb |
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| Authors: | Hiroyuki Yamauchi Kazue Honma Kazuki Mochizuki |
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| Institution: | 1. Laboratory of Nutritional Physiology, Department of Nutrition, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka , Shizuoka, Japan;2. Laboratory of Food and Nutritional Sciences, Faculty of Life and Environmental Sciences, Department of Local Produce and Food Sciences, University of Yamanashi , Yamanashi, Japan |
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| Abstract: | Jejunal sodium/glucose co-transporter (Sglt1) displays circadian expression. The jejunum was collected every 4 h from mice, and we examined histone acetylation and binding of bromodomain-containing protein-4 (BRD4) around of the gene. Histone acetylation increased in the transcribed region of Sglt1 prior to induction of the gene. Furthermore, the binding of mRNA elongation factor around the gene showed circadian rhythm. |
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| Keywords: | Circadian rhythm small intestine SGLT1 histone acetylation |
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