Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation,tau phosphorylation,and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice |
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Authors: | Satoshi Okuyama Wakana Shinoka Kumi Nakamura Maho Kotani Atsushi Sawamoto Kuniaki Sugawara |
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Institution: | 1. Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University , Matsuyama, Japan;2. Department of Planning and Development, Ehime Beverage Inc. , Matsuyama, Japan |
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Abstract: | We previously reported that the dried peel powder of Citrus kawachiensis exerted anti-inflammatory effects in the brain in several animal models. Hyperglycemia induces inflammation and oxidative stress and causes massive damage in the brain; therefore, we herein examined the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the streptozotocin-induced hyperglycemia mice model and in the type 2 diabetic db/db mice model. The C. kawachiensis administration inhibited microglial activation in the hippocampus in the streptozotocin-injected mice. Moreover, The C. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau at 231 of threonine and 396 of serine in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the db/db mice. It was suggested that the dried peel powder of C. kawachiensis exerts anti-inflammatory and neuroprotective effects in the brain. |
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Keywords: | Citrus kawachiensis db/db mice neurogenesis tau phosphorylation anti-inflammation |
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