Differential control of proto-oncogene c-myc and c-fos expression in lymphocytes and fibroblasts. |
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Authors: | R McNerney D Darling A Johnstone |
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Affiliation: | Department of Immunology, St. George's Hospital Medical School, London, U.K. |
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Abstract: | In lymphocytes stimulated with the mitogen phytohaemagglutinin, an inhibitor of the enzyme ADP-ribosyltransferase (ADPRT) completely blocks the proliferative response and the increase in expression of the proto-oncogene c-myc without affecting c-fos significantly. Conversely, in fibroblasts the serum-induced growth is not affected by the ADPRT inhibitor, and both oncogenes are dramatically super-induced. Hence there are differences between lymphocyte and fibroblast early responses to mitogenic stimulation and also between regulation of c-fos and c-myc gene expression. |
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