The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of <Emphasis Type="Italic">Plasmodium falciparum</Emphasis> |
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Authors: | Rowena?E?Martin Roselani?I?Henry Janice?L?Abbey John?D?Clements Email author" target="_blank">Kiaran?KirkEmail author |
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Institution: | (1) School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT, 0200, Australia;(2) Division of Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 0200, Australia |
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Abstract: | Background The uptake of nutrients, expulsion of metabolic wastes and maintenance of ion homeostasis by the intraerythrocytic malaria
parasite is mediated by membrane transport proteins. Proteins of this type are also implicated in the phenomenon of antimalarial
drug resistance. However, the initial annotation of the genome of the human malaria parasite Plasmodium falciparum identified only a limited number of transporters, and no channels. In this study we have used a combination of bioinformatic
approaches to identify and attribute putative functions to transporters and channels encoded by the malaria parasite, as well
as comparing expression patterns for a subset of these. |
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Keywords: | |
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