Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity |
| |
Authors: | Strowig Till Brilot Fabienne Münz Christian |
| |
Affiliation: | Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA. |
| |
Abstract: | Natural killer cells were named after their ability to mediate spontaneous cytotoxicity during innate immune responses. However, it has become clear in recent years that they play an equally important role in restricting infections and assisting the development of adaptive immune responses via their ability to produce cytokines. In humans, a dedicated NK cell subset primarily fulfills these later functions. In this review we discuss the noncytotoxic effector functions of NK cells and how they could be harnessed for immunotherapy and vaccine development. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|