A novel human derived cell-penetrating peptide in drug delivery |
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Authors: | Jian Zhao Peng Gao Wei Xiao Li-Qiang Fan Fu-Jun Wang Su-Xia Li Jian-Wen Liu |
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Affiliation: | (1) State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Mailbox 365, 130 Meilong Road, Shanghai, 200237, People’s Republic of China;(2) Zhejiang Reachall Pharmaceutical Co. Ltd, Zhejiang, 322100, China |
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Abstract: | Cell-penetrating peptides can carry a variety of biologically active molecules into cells. Here we have identified a novel CPP derived from the C-terminus of human extracellular superoxide dismutase (hC-SOD3) which was shown to be located throughout in the cytoplasm and nucleus by fluorescence microscopy investigation. Furthermore, when apoptin fused to hC-SOD3, it was translocated efficiently into HeLa cells resulting in antitumor activities. This study shows that hC-SOD3 has the potential to penetrate and translocate cargo molecules into cells and has no cytotoxicity at effective concentration. |
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