Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer |
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Authors: | Ghalia Khoder Yoshio Yamaoka Jean-Louis Fauchère Christophe Burucoa Christo Atanassov |
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Affiliation: | 1. EA 4331 LITEC, Université de Poitiers, France;2. Veteran Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA |
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Abstract: | Protein patterns of 129 Helicobacter pylori strains isolated from Korean and Colombian patients suffering from duodenal ulcer or gastric cancer were analyzed by the high-throughput methodology SELDI-TOF-MS. Eighteen statistically significant candidate biomarkers discriminating between the two clinical outcomes were selected by using the Mann–Whitney test. Three biomarker proteins were purified and identified as a neutrophil-activating protein NapA (HU HPAG1_0821), a RNA-binding protein (HPAG1_0813), and a DNA-binding histone-like protein HU, respectively (jhp0228). These novel biomarkers can be used for development of diagnostic assays predicting the evolution to gastric cancer in H. pylori-infected patients. |
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