Cross-reaction of two different somatostatin antisera with calcitonin gene-related peptide |
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| Authors: | J Ishizuka C Yanaihara N Yanaihara G H Greeley C W Cooper J C Thompson |
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| Affiliation: | Department of Surgery, University of Texas Medical Branch, Galveston. |
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| Abstract: | Two different anti-somatostatin antisera, R-101 and OAL-273, cross-react with rat calcitonin gene-related peptide (1-37) (CGRP). CGRP amounts, in excess of 6.25 x 10(-9) M, cross-react with R-101 in the somatostatin radioimmunoassay. CGRP amounts, in excess of 1.6 x 10(-9) M, cross-react with OAL-273. Both CGRP displacement curves are parallel to that of synthetic somatostatin (1-14). Comparison of ID50's shows that the cross-reactivity of CGRP with R-101 and OAL-273 are 0.02 and 0.1% of somatostatin, respectively. |
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