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New artificial siderophores based on a monosaccharide scaffold |
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| Authors: | Susanne Heggemann Matthias Schnabelrauch Dieter Klemm Ute Möllmann Rolf Reissbrodt Lothar Heinisch |
| Affiliation: | (1) Hans Knöll-Institut für Naturstoff-Forschung, Jena, Germany;(2) Institut für Organische Chemie und Makromolekulare Chemie, FSU Jena, Germany;(3) Robert Koch-Institut, Bereich Wernigerode, Wernigerode, Germany |
| Abstract: | New artificial catecholate siderophores with methyl  -d-glucopyranoside as scaffold were synthesized. The dihydroxy- or di(acetoxy)benzoyl moieties were attached either directly or via aminopropyl spacer groups, to the carbohydrate scaffold. The siderophore activity of the prepared siderophore analogs was examined by a growth promotion assay using various Gram-negative bacteria and mycobacteria and by the CAS-assay. |
| Keywords: | biscatecholates Gram-negative bacteria monosaccharides mycobacteria siderophore analogs synthesis triscatecholates |
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