A murine model for the study of the impact ofAspergillus fumigatus inoculation on the foeto-placental unit |
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Authors: | Henrik Elvang Jensen Jann Hau |
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Affiliation: | (1) Toxicology and Mycotoxin Research Unit, U.S. Department of Agriculture, Agricultural Research Service, R.B. Russell Agricultural Research Center, 30613 Athens, GA, USA;(2) U.S. Department of Agriculture, Agricultural Research Service, National Peanut Research Laboratory, 31742 Dawson, GA, USA |
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Abstract: | The mycotoxin cyclopiazonic acid (CPA) is a potential contaminant of processed foods, grain and poultry. Twelve male Sprague-Dawley rats were given oral doses of 0, 0.2, 0.6, 2.0 or 4.0 mg CPA/kg body weight/day for 13 consecutive weeks to study its potential subchronic toxicity. No dose-related mortality or morbidity occurred. General appearance, behavior, body weight gain and food consumption of all groups were similar. CPA had no definite adverse hematologic or serum chemistry effects, although serum creatinine concentrations of rats given 2.0 and 4.0 mg CPA/kg BW were increased after seven and 13 weeks. Mild to focally moderate acute inflammation of the lamina propria and submucosa of the gastric epithelium was found in animals given 0.6 mg CPA/kg BW. No other dose-related microscopic lesions were found. Ultrastructural examination of the livers revealed subtle disruption of the cisternal pattern of the endoplasmic reticulum with ribosomal detachment in animals receiving 4.0, but not 2.0, mg CPA/kg BW. These data suggest that the toxic effects in rats of repeated, daily oral exposure to CPA may be less than previously reported. The possible relationship between toxicity and CPA epimerization is considered. |
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Keywords: | oral toxicity cyclopiazonic acid |
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