Genetics and iron in the systems biology of Parkinson’s disease and some related disorders |
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| Authors: | Claudia Funke Susanne A. Schneider Daniela Berg Douglas B. Kell |
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| Affiliation: | 1. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller-Strasse 27, 72076 Tübingen, Germany;2. Department of Neurology, University Kiel, Arnold Heller Str. 3, 24105 Kiel, Germany;3. Department of Clinical Neuroscience, Imperial College London, Charing Cross Campus, London, UK;4. DZNE, German Center of Neurodegenerative Diseases, Tübingen, Germany;5. School of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess St., Manchester M1 7DN, UK |
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| Abstract: | The systems biology approach to complex diseases recognises that a potentially large number of biochemical network elements may be involved in disease progression, especially where positive feedback loops can be identified. Most of these network elements will be encoded by genes, for which different alleles may affect the network(s) differentially. A primary requirement is therefore to determine the relevant gene-network relationships. A corollary of this is that identification of the network should thereby allow one to ‘explain’ or account for any genetic associations. |
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| Keywords: | LB, Lewy body PD, Parkinson&rsquo s disease SN, substantia nigra ROS, reactive oxygen species IRE/IRP, iron responsive element/iron responsive protein NBIA, neurodegeneration with brain iron accumulation KRS, Kufor-Rakeb syndrome LRRK2, leucine rich repeat kinase 2 GBA, Glucocerebrosidase INAD, infantile neuroaxonal dystrophy AD, Alzheimer&rsquo s disease MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine AP, amyloid plaque MRI, magnetic resonance imaging TCS, transcranial sonography |
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