Energy metabolism of cerebral mitochondria during aging,ischemia and post-ischemic recovery assessed by functional proteomics of enzymes |
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| Authors: | Roberto Federico Villa Antonella Gorini Federica Ferrari Siegfried Hoyer |
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| Affiliation: | 1. Department of Biology and Biotechnology, Laboratory of Pharmacology and Molecular Medicine of Central Nervous System, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy;2. Department of Pathology, University Clinic, University of Heidelberg, Im Neuenheimer Feld 220/221, 69120 Heidelberg, Germany |
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| Abstract: | Stroke is a leading cause of death and disability, but most of the therapeutic approaches failed in clinical trials. The energy metabolism alterations, due to marked ATP decline, are strongly related to stroke and, at present, their physiopathological roles are not fully understood. Thus, the aim of this study was to evaluate the effects of aging on ischemia-induced changes in energy mitochondrial transduction and the consequences on overall brain energy metabolism in an in vivo experimental model of complete cerebral ischemia of 15 min duration and during post-ischemic recirculation after 1, 24, 48, 72 and 96 h, in 1 year “adult” and 2 year-old “aged” rats. |
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| Keywords: | Brain energy metabolism Ischemia Recirculation Enzymes Mitochondria Aging |
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