Prebiotic feeding elevates central brain derived neurotrophic factor,N-methyl-d-aspartate receptor subunits and d-serine |
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| Authors: | Helene M. Savignac Giulia Corona Henrietta Mills Li Chen Jeremy P.E. Spencer George Tzortzis Philip W.J. Burnet |
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| Affiliation: | 1. Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK;2. School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 9AR, UK;3. Clasado Research Services Ltd., Reading RG6 6BZ, UK |
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| Abstract: | The influence of the gut microbiota on brain chemistry has been convincingly demonstrated in rodents. In the absence of gut bacteria, the central expression of brain derived neurotropic factor, (BDNF), and N-methyl-d-aspartate receptor (NMDAR) subunits are reduced, whereas, oral probiotics increase brain BDNF, and impart significant anxiolytic effects. We tested whether prebiotic compounds, which increase intrinsic enteric microbiota, also affected brain BDNF and NMDARs. In addition, we examined whether plasma from prebiotic treated rats released BDNF from human SH-SY5Y neuroblastoma cells, to provide an initial indication of mechanism of action. |
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| Keywords: | Bifidobacteria Dentate gyrus Glutamate HPLC Western blot Amino acids |
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