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Motor behavior correlates with striatal [F]-DOPA uptake in MPTP-lesioned primates |
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| Authors: | R. Kortekaas S.A. Eshuis G. Andringa A.R. Cools K.L. Leenders |
| Affiliation: | 1. Department of Neuroscience, University Medical Center Groningen, University of Groningen, The Netherlands;2. Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands;3. Department of Psychoneuropharmacology, Route 155, Molecular Neurobiology, Donders Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Geert Grooteplein Noord 21a, 6500 HB Nijmegen, The Netherlands |
| Abstract: | The MPTP-lesioned monkey is considered as the best animal model for Parkinson’s disease (PD). It has damage to dopaminergic cell groups and motor dysfunction similar to that seen in PD. Correlations between these two parameters have been described but there is a lack of formal statistical analyses on dopaminergic function as assessed by [18F]-F-DOPA PET and objectively rated motor behavior in longitudinal experiments. |
| Keywords: | MPTP Parkinson&rsquo s disease Primates [18F]-F-DOPA PET Movement disorders |
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