Evolution of the CD163 family and its relationship to the bovine gamma delta T cell co-receptor WC1 |
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| Authors: | Carolyn TA Herzig Ray W Waters Cynthia L Baldwin Janice C Telfer |
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| Institution: | (1) Department of Veterinary and Animal Sciences, Paige Laboratory, University of Massachusetts Amherst, 01003 Amherst, MA, USA;(2) National Animal Diseases Center, USDA-ARS, 50010 Ames, Iowa, USA |
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| Abstract: | Background The scavenger receptor cysteine rich (SRCR) domain is an ancient and conserved protein domain. CD163 and WC1 molecules are
classed together as group B SRCR superfamily members, along with Spα, CD5 and CD6, all of which are expressed by immune system
cells. There are three known types of CD163 molecules in mammals, CD163A (M130, coded for by CD163), CD163b (M160, coded for by CD163L1) and CD163c-α (CD163L1 or SCART), while their nearest relative, WC1, is encoded by a multigene family so far identified in
the artiodactyl species of cattle, sheep, and pigs. |
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