MT2 Melatonin Receptor Immunoreactivity in Neurons is Very High in the Aged Hippocampal Formation in Gerbils |
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| Authors: | Choong Hyun Lee Jung Hoon Choi Ki-Yeon Yoo Ok Kyu Park In Koo Hwang Sang Guan You Boo-Yong Lee Il-Jun Kang Moo-Ho Won |
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| Institution: | (1) Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(2) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(3) Marine Food Science and Technology, Kangnung-Wonju National University, Gangneung, 210-702, South Korea;(4) Department of Biomedical Science, CHA University, Seongnam, 463-836, South Korea;(5) Department of Food Science and Nutrition, Hallym University, Chuncheon, 200-702, South Korea; |
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| Abstract: | Melatonin exerts many physiological functions via its G protein-coupled receptors. In the present study, we investigated age-related
changes in MT2 melatonin receptor immunoreactivity and its levels in the gerbil hippocampus during normal aging. In the postnatal
month 1 (PM 1) group, MT2 immunoreaction was well observed in neurons in all subregions of the gerbil hippocampus. In the
PM 3 and 6 groups, MT2 immunoreactivity in neurons was decreased compared to that in the PM 1 group. Thereafter, MT2 immunoreactivity
in neurons was increased. In the PM 18 and 24 groups, MT2 immunoreactivity in neurons was strong in all subregions of the
gerbil hippocampus. In addition, the number of MT2 immunoreactive cells was lowest at PM 3 and highest at PM 24. From western
blot analysis, age-dependent change pattern in MT2 level in the gerbil hippocampus was similar to the immunohistochemical
result. These results indicate that MT2 immunoreactivity and levels are altered in the gerbil hippocampus during normal aging;
lowest at young adult stage and highest at aged stage. |
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