The Effects of the Organic Flame‐Retardant 1,2‐Dibromo‐4‐(1,2‐dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines |
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| Authors: | Lilian I L Wong Alexandra R Reers Heidi A Currier Tony D Williams Michael E Cox John E Elliott Timothy V Beischlag |
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| Institution: | 1. Department of Biological Sciences, Simon Fraser University, Burnaby, Canada;2. The Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, Canada;3. Pacific Wildlife Research Center, Environment Canada, Delta, Canada;4. Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada |
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| Abstract: | The effects of the organic flame retardant 1,2‐Dibromo‐4‐(1,2‐dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ‐/δ‐TBECH alone led to a significant increase in prostate‐specific antigen (PSA) mRNA accumulation, both the α‐/‐TBECH and γ‐/δ‐TBECH mixtures repressed androgen‐inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor. |
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| Keywords: | Organic Flame Retardant Endocrine Disruptor Androgen Receptor LNCaP |
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