Short-term therapy of atherosclerosis with low dose indomethacin: an experimental study |
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Authors: | V Dhawan N K Ganguly S Majumdar R N Chakravarti |
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Affiliation: | Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
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Abstract: | The effects of low dose indomethacin therapy in primary prevention of diet-induced atherosclerosis of rhesus monkeys was studied. The parameters studied were serum cholesterol concentration, thromboxane A2 (T x B2), prostacyclin (6-keto-PGF1 alpha) in serum/plasma, and the extent and intensity of coronary atherosclerosis. Although indomethacin did not affect serum cholesterol, it reduced serum T x B2 significantly (P less than 0.01). Plasma 6-keto-PGF1 alpha was not restored to the pretreatment level. A significant protective role of the drug was noted as far as coronary atherosclerosis is concerned (P less than 0.01). |
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Keywords: | Thromboxane Prostacyclin Rhesus monkey Macaca mulatta |
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