Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice |
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| Authors: | Kim Byoung Chul Kang Tae-Jin Jin Song Hou Kim Se-Kon Lee Seong-Boem Chae Gue-Tae |
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| Institution: | Institute of Hansen's Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea. |
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| Abstract: | RIPK 2 is adapter molecule in the signal pathway involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was up-regulated in the liver of Mycobacterium leprae-infected nu/nu mice compared with those of the M. leprae non-infected nu/nu mice. It was observed that the interlukin-12p40 and interferon-gamma genes involved in the susceptibility of M. leprae were down-regulated in the skin but were up-regulated in the liver. Overall, this suggests that regulation of RIPK 2 expression is tissue-specifically associated with M. leprae infection. |
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