Human muscle glutathione S-transferase (GST-4) shows close homology to human liver GST-1 |
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| Authors: | P G Board T Suzuki D C Shaw |
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| Affiliation: | Department of Human Genetics, John Curtin School of Medical Research, Australian National University, Canberra. |
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| Abstract: | Human muscle specific glutathione S-transferase (RX: glutathione R-transferase, EC 2.5.1.18) (GST-4) and liver GST-1 have been purified and subjected to N-terminal sequence analysis. These two isozymes show close homology and only differ in 3 residues within the first 24. The N-terminal sequences of GST-1 and GST-4 differ significantly from those of GST-2 and GST-3. Although antiserum raised against native GST-1 did not cross-react with GST-4, cross-reactivity was obtained with antiserum raised against denatured GST-1. The homology between GST-1 and GST-4 indicates that they are both members of the mu evolutionary class. |
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