Optimization strategies for metabolic networks |
| |
Authors: | Alexandre Domingues Susana Vinga João M Lemos |
| |
Institution: | 1.INESC-ID - R,Lisboa,Portugal;2.FCM-UNL - C Mártires,Lisboa,Portugal;3.IST-UTL,Lisboa,Portugal |
| |
Abstract: | Background The increasing availability of models and data for metabolic networks poses new challenges in what concerns optimization for
biological systems. Due to the high level of complexity and uncertainty associated to these networks the suggested models
often lack detail and liability, required to determine the proper optimization strategies. A possible approach to overcome
this limitation is the combination of both kinetic and stoichiometric models. In this paper three control optimization methods,
with different levels of complexity and assuming various degrees of process information, are presented and their results compared
using a prototype network. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|