Ultrasensitive Responses and Specificity in Cell Signaling |
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| Authors: | Seth Haney Lee Bardwell Qing Nie |
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| Affiliation: | (1) Department of Mathematics, University of California at Irvine, 92697 Irvine, CA, USA;(2) Department of Developmental and Cell Biology, University of California at Irvine, 92697 Irvine, CA, USA;(3) Center for Complex Biological Systems, University of California at Irvine, 92697 Irvine, CA, USA;(4) Center for Mathematical and Computational Biology, University of California at Irvine, 92697 Irvine, CA, USA |
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| Abstract: | Background Interconnected cell signaling pathways are able to efficiently and accurately transmit a multitude of different signals, despite an inherent potential for undesirable levels of cross-talk. To ensure that an appropriate response is produced, biological systems have evolved network-level mechanisms that insulate pathways from crosstalk and prevent 'leaking' or 'spillover' between pathways. Many signaling pathways have been shown to respond in an ultrasensitive (switch-like) fashion to graded input, and this behavior may influence specificity. The relationship of ultrasensitivity to signaling specificity has not been extensively explored. |
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