A prostate cancer vaccine comprising whole cells secreting IL-7, effective against subcutaneous challenge,requires local GM-CSF for intra-prostatic efficacy |
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| Authors: | Caroline Schroten-Loef Corrina M A de Ridder Suzanne Reneman Marije Crezee Angus Dalgleish Stephen M Todryk Chris H Bangma Robert Kraaij |
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| Institution: | (1) Erasmus MC, Department of Urology, Josephine Nefkens Institute, Room Be355A, P.O. Box 2040, 3000, CA, Rotterdam, The Netherlands;(2) Department of Oncology, St. George’s University of London, London, UK;(3) School of Applied Sciences, University of Northumbria, Newcastle-upon-Tyne, UK |
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| Abstract: | A panel of cytokine-secreting RM-9 prostate cancer cells were tested as whole cell vaccines to determine their capacity to
evoke an anti-prostate cancer immune response. In our model, vaccines secreting mGM-CSF or mIL-7 resulted in the highest increase
in circulating T lymphocytes after vaccination, prolonged survival and, in a proportion of animals, tumor-free survival. Anti-tumor
effects were more evident after a subcutaneous RM-9 challenge than after an intraprostatic challenge. However, when the RM-9/mGM-CSF
cell line was used as intraprostatic tumor challenge, protection after RM-9/mIL-7 vaccination was restored. |
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| Keywords: | Immunotherapy Whole cell vaccine Cytokines Prostate cancer MPR-model |
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