Human methionine aminopeptidase type 2 in complex with L- and D-methionine |
| |
Authors: | Nonato M Cristina Widom Joanne Clardy Jon |
| |
Affiliation: | Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, USA. |
| |
Abstract: | Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|