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SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation |
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| Authors: | Qiuhui Pan Songhai Yang Youzhen Wei Zhi Li |
| Institution: | a The Central Laboratory, People’s 10th Hospital, Shanghai 200072, PR China b The Department of Internal Medicine, Zhongcun Hospital, Panyu, Guangzhou 511495, PR China c Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China d The Department of Medical Laboratory, People’s 10th Hospital, Shanghai 200072, PR China |
| Abstract: | ADAM23 modulates many cellular functions, alteration of expression causes a number of tumor types; however, the mechanisms controlling ADAM23 expression remain unknown. Here we have identified a SP1 binding site (−202/−190) that binds SP1 at the proximal promoter of human ADAM23 gene; furthermore, serum deprivation enhances open chromatin accessibility and help expose the SP1 binding site; finally, SP1 binding recruits RNA polymerase II, which in turn results in upregulation of endogenous ADAM23 expression. Therefore, the present study delineates the fundamental elements of a core promoter structure that will be helpful for future studies of the regulation of ADAM23 gene. |
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