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Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells |
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| Authors: | Ishikado Atsushi Nishio Yoshihiko Morino Katsutaro Ugi Satoshi Kondo Hajime Makino Taketoshi Kashiwagi Atsunori Maegawa Hiroshi |
| Institution: | a Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa-Cho, Otsu, Shiga 520-2192, Japan b Research & Development Department, Sunstar Inc., 3-1, Asahi-Machi, Takatsuki, Osaka 569-1195, Japan |
| Abstract: | |
| Keywords: | n-3 PUFA n-3 polyunsaturated fatty acid 4-HHE 4-hydroxy hexenal HO-1 heme oxygenase-1 Nrf2 nuclear factor erythroid 2-related factor 2 4-HNE 4-hydroxy nonenal Keap1 Kelch-like ECH-associated protein 1 NQO1 NAD(P)H quinone oxidoreductase 1 ARE antioxidant response element tBHP tert-butyl hydroperoxide MTT 3-(4 5-dimethyl-2-thiazolyl)-2 5-diphenyl-2H-tetrazolium bromide |
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