Comparative analysis of haplotype association mapping algorithms |
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Authors: | Phillip McClurg Mathew T Pletcher Tim Wiltshire and Andrew I Su |
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Institution: | (1) Genomics Institute of the Novartis Research Foundation, San Diego, USA;(2) The Scripps Research Institute, West Palm Beach, Jupiter, FL, 33458, USA |
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Abstract: | Background Finding the genetic causes of quantitative traits is a complex and difficult task. Classical methods for mapping quantitative
trail loci (QTL) in miceuse an F2 cross between two strains with substantially different phenotype and an interval mapping
method to compute confidence intervals at each position in the genome. This process requires significant resources for breeding
and genotyping, and the data generated are usually only applicable to one phenotype of interest. Recently, we reported the
application of a haplotype association mapping method which utilizes dense genotyping data across a diverse panel of inbred
mouse strains and a marker association algorithm that is independent of any specific phenotype. As the availability of genotyping
data grows in size and density, analysis of these haplotype association mapping methods should be of increasing value to the
statistical genetics community. |
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